Its been decided that its time to change my immunosuppressive drugs again. My lab results have been indicating that my kidneys are becoming stressed by my current immunosuppressive regimen. My creatinine is up to 1.8 and seems to be higher with each reading.
I could see this coming for awhile, but its still somewhat of a shock. Other than worrying over lab results, I'm really not experiencing any symptoms.
To review, this will be my third switch. I began with Rapamune and Raptiva. Raptiva is the name of the clinical trial that I am participating in and was a new drug being tested for islet cell transplant recipients. In hindsight, it was wonderful. I took one injection once a week. No pills at all. And no side effects either. Then, after about 9 months, Raptiva was taken off the market. It was also used for psoriasis patients and some of those patients were having problems with it. They were experiencing a certain type of brain infection and there were a few deaths. It was decided to discontinue its use in the islet cell recipients at that point.
So, I was switched to Prograf and Cellcept. Everything was fine for awhile. My islets seemed to work well with this combo and everything seemed to be going smoothly. Then, I started having some digestive issues. I treated and fought with them for about 9 months, but ended up with colitis. It seemed to be progressing from bad to worse, so it was decided to take me off of the Cellcept.
I switched from Cellcept back to Rapamune. I've been on this Prograf/Rapamune combination for two years now. Its been uneventful for the most part. Very minimal and temporary symptoms. But, my blood sugars increased which is when I began to need some insulin again. And then the kidney function tests began to show signs of kidney stress. It seems that every time I've been drawn lately, its triggered calls from my doctors. I see a nephrologist who seems the least worried, but she seems comfortable with the words "dialysis" and "kidney transplant".